An effective vaccination for COVID-19, officials have been saying since the crisis began this winter, could be a year or more away.
In the meantime, scientists and the broader medical community are feverishly looking for ways to mitigate a virus that, at times with seeming randomness, spares many who catch it while bringing others to death's door. Or through it.
Texas A&M University researchers, in concert with Harvard University and top hospitals in Texas and Los Angeles, this week are commencing a human trial with a drug that some international data indicates could be a promising interim treatment for COVID-19: the BCG vaccine, or bacille Calmette-Guerin. BCG wouldn't prevent COVID-19 entirely, but researchers are looking to prove that it could dampen the effects of the disease, creating a "trained immunity" that would save lives and curb the ravages of the disease in other cases.
The study is primarily funded with a $2.5 million grant from the Texas A&M system.
"If we get the data out in the next few months showing even a 10% effect on COVID-19, we could save hundreds, if not thousands, of lives," said Dr. Jeffrey Cirillo, a researcher in infectious and respiratory diseases with the Texas A&M Health Science Center in College Station. He said solid results would be available within a half year. "It allows us to buy time until we have a specific COVID-19 vaccine available."
Dr. Jeffrey Cirillo, Texas A&M University Health Science Center
Dr. Jeffrey Cirillo of Texas A&M University Health Science Center said results of the study could be available with six months.
"If there was ever a time to invest in medical research, it is now," A&M Chancellor John Sharp said in a statement released by the A&M system. "I want to make sure [Cirillo] has what he needs to protect the world from more of the horrible effects of this pandemic."
But Cirillo had two cautions against the sort of overexuberance that has led some people to prematurely pursue remedies mentioned by politicians or the media.
The clinical trial, first of all, is in its infancy. Recruitment of a hoped-for 1,800 frontline medical workers to volunteer in the randomized, double-blind study is just beginning, with only 30 on board as of Tuesday. That includes about a dozen participants in Round Rock, Cirillo said. Actual BCG vaccinations (or, in half the cases, a placebo) won't begin until clinicians have at least 100 volunteers.
(A&M asks medical workers in College Station, Temple, greater Austin, Dallas and Houston to contact Cirillo at: firstname.lastname@example.org.)
Beyond that, while the vaccine is FDA-approved for bladder cancer treatment and thus safe, just how much it buttresses immune systems against the effects of COVID-19 remains unclear.
"What we have seen in other contexts is that BCG has a positive effect on the immune response to viral and bacterial infections," Cirillo said. "But we're really trying to get people to be cautious and not try to get the vaccine at this point."
BCG has been in use since 1921 as a vaccination for childhood tuberculosis in at least 20 developing countries—hundreds of thousands of young children get it each year, he said—and more recently in the U.S. and other countries to fight cancer. It has not been used typically as a vaccination in the United States because of the extremely low rates of childhood TB here.
But according to a COVID-19 statistical review released in the past few weeks by an M.D. Anderson professor and three co-authors—a study still under peer review—countries that do not use it as a TB vaccination in children have almost 10 times the incidence of COVID-19 infection. And the combined fatality rate from COVID-19—40 deaths per million residents—in about 155 countries without BCG vaccinations likewise is almost 10 times greater than in the 21 countries with widespread vaccination.
The World Health Organization, in a notice on its website about that comparison, warns against making too much of those numbers. Such studies, WHO says, could be subject to "significant bias" caused by unexplored differences between countries in "demographics and disease burden, testing rates for COVID-19 virus infections, and the stage of the pandemic in each country."
Cirillo said that his hopes for BCG are not based primarily on those numbers, in any case, because the effects of vaccinating infants would be unlikely to persist into adulthood. Instead, he said, other epidemiological studies of adult usage of the drug have shown mitigation of viral and other respiratory diseases.
And that beneficial effect occurs quickly, he said.
"In most cases, it appears to occur almost immediately, within a few days [of vaccination] to a certain degree," Cirillo said. "Certainly within two to three months, you see a fairly robust response."
Already, a clinical trial of a similar strain of BCG (one not approved by the FDA) with 4,000 people in Australia is underway, and Cirillo said it, too, holds promise. But Cirillo said manufacturing capacity already exists in the U.S. for the BCG variety in the A&M study with pharmaceutical giant Merck, as well as in factories in Canada, India and Italy.
"I think we can do it," if the drug proves beneficial in the coming months, Cirillo said. "It has been produced at a national scale in the past. So ramping up would not take as long as other vaccines."
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This Gemini season, starting today, is appropriately paradoxical, twisting and blending simple concerns with life’s bigger, faster and more fiery quests.
On Sunday, May 29, we’ll experience one of the year’s biggest calls to adventure in the Mars/Jupiter conjunction—a potent duo whose combined force will start to be especially strongly felt when Mars moves into Aries on May 24. Contrastingly, Mercury, the ruler of Gemini, will keep our mental temperament grounded and steady as they move slowly through the sensual, materially-oriented sign of Taurus for most of the month. These contrasting forces might be tricky to weave together—read ahead for tips on how your sign can find the right approach this month!
Gemini: May 21-June 20Gemini: May 21-June 20
Welcome to the season of your Solar Return, Gemini! This month will set the stage for your whole coming year, so it will be great to start it off on the right foot. The most important bit of cosmic context is Mercury moving slowly till the end of the month in the grounded sign of Taurus. This is an encouragement to savor your questions and conversations with the world, without needing to rush to answers and to mull over the elemental, fundamental aspects of your life. It would be great to give yourself perspective, especially by experiencing new environments and by moving through the world in a new manner. Allow yourself to be surprised! You might loosen some of your hardened beliefs, but don’t discount the trustworthiness or substance of the new ideas you may stumble upon.
Cancer: June 21-July 22Cancer: June 21-July 22
For you, Cancer, the paradoxes of Gemini season have to do with inwardness and outwardness. On the one hand, you can expect your inner world to be as active as ever, swirling with meaningful thoughts and experiences needing to be digested. On the other, this month features a strong call to get out of your shell, open up to the world at large, and bravely share yourself—perhaps even in an unprecedented way! In transitioning between these extremes, the Moon can be as good a guide as ever—heading into and out of the New Moon on the 30th, you might focus on articulating and envisioning this burgeoning impulse and nourishing the terrain for its growth. As we ramp up to the full moon on the 14th, you might find small ways to embody, communicate and make real this developing dream.
Leo: July 23-Aug 22Leo: July 23-Aug. 22
This Gemini Season is particularly intense for you, Leo, as it calls forth both a fiery, hungry spirit and a more serious, dedicated energy, aware of life’s hardships and limitations. These impulses herald a summer of growth and maturation, which would be great to get a good jump on. Just don’t let this process make you too heavyhearted or self-involved! Your friends, community, and experience of the broader social world at large can help soften and clarify this strong, fiery self that’s metamorphosing. You might rely upon this bigger, human perspective to help you progress smoothly and gracefully. Although it might require some extra humility, taking yourself less seriously can be a superpower. A lighthearted approach can be extraordinarily efficient and effective. It might be paradoxical, but consider that relying on a bigger, greater power than your own is your path to individual fullness.
Virgo: Aug. 23-Sept. 21Virgo: Aug. 23-Sept. 21
This Gemini season brings a charge for you to expand into more substantive and serious subjects, Virgo. Especially if you feel you’ve been playing small, this will provide an opportunity for you to grow into more meaningful and demanding work in the world. At times, this will feel hectic and harsh—there will be no shortage of fire this month. You, as much as anyone, though, can help find the right place and time for that fire, directing it where there’s a need for more energy and oomph. Lightheartedness can be really helpful in navigating and dancing with this heat—with a bit of humor and perspective, you can respond and adapt quickly and gracefully. By the end of the month, you should be able to feel like your view of and faith in the bigger picture has expanded.
Libra: Sept. 22-Oct. 23Libra: Sept. 22-Oct. 23
This Gemini season will provide ample opportunities for you to learn and grow through your relationships, Libra. We’re really looking at the full spectrum of potential experiences here—on the one hand, Mars’ entry into Aries can ignite flammable subjects, and people are generally likely to be on edge, assertive and protective. On the other, Venus’ conjunction with Uranus toward the end of the month can bring unexpected encounters and new forms of relationship into play. Throughout all of this, there’s a theme for the next year of growth through fiery, direct relationships. This is a step beyond just keeping the peace which may be discomforting, but consider that it may take your relationships to incredibly satisfying and enduring places.
Scorpio: Oct. 24-Nov. 21Scorpio: Oct. 24-Nov. 21
This Gemini season brings opportunities for sharpening both your wits and tools, Scorpio, although this may feel like a trial by fire. Although they may feel particularly urgent and exciting this month, many of these challenges and opportunities will last throughout the summer, so take your time to get your focus clear and settle into a groove. The real challenge and potential this month have to do with navigating subtle, intricate dynamics so that you aren’t flustered and know exactly where to put your effort. In order to develop this discernment, you can definitely rely on trusted allies, who can act as mirrors, triangulation points and simple safe havens amid the storm. This is a strategic necessity, but be sure to give thanks and enjoy the simple goodness of companionship, too!
Sagittarius: Nov. 22-Dec. 21Sagittarius: Nov. 22-Dec. 21
The sharp, powerful impulses and stimulation of this Gemini season are pushing you to the development of your free will, Sagittarius—a spirit of playful, proud independence and spontaneity. There are a couple of ways that you might think about this. First, that courage is necessary to truly live out your convictions and ideals, as well as a way to ultimately best serve the world. Truth isn’t always soft or easy. On the other hand, this isn’t too complex and is keyed to cutting through stagnation. There’s a sort of simplicity and instinctive wisdom that you can draw upon and develop into this month, letting things happen. If you need to, you can think of this as an act of trust, or faith in a basic goodness and natural, flowing order of things.
Capricorn: Dec. 22-Jan. 19Capricorn: Dec. 22-Jan. 19
The motion and activity of this Gemini season can quickly develop your values and taste, Capricorn, as you strip back ordinary and inherited ways of thinking and open your eyes to life’s beauty. This simple and vibrant beauty will stimulate your desire to savor life’s goodness and strive for the highest quality experience possible. Along the way, your fixed, limited ideas about what is possible can fall away, even as the new and extraordinary may require incredible strength and devotion from you. Although these are lofty ideals, they’ll have a lot to do with your tangible, everyday experience of your body and sense of home—this is a primal, almost wild energy being rekindled. Alongside this intense fire comes a certain risk, so make sure to enter into this new adventure step by step, without injuring yourself or anyone else.
Aquarius: Jan. 20-Feb. 18Aquarius: Jan. 20-Feb. 18
This Gemini season can help you learn how to feel more rooted and alive in life’s simple aspects, Aquarius. Although this can certainly take place in tandem with new teachers, these don’t have to be big gurus—rather, your curiosity, delight, and common sense might be the best guides. In this regard, your quality of perception, thought and the well-being of your inner child can all make great strides. Through the first part of the month, this will likely feel exciting and overwhelming. As we approach our new moon, though, you can get a better sense of where you need to be settling into more focus and definition in your life. This back and forth between a growing sense of clarity and inner authority and a stronger capacity to be firm and to the point will continue to deepen throughout the summer.
Pisces: Feb. 19-March 20Pisces: Feb. 19-March 20
This Gemini season is focused on helping you develop a stronger sense of connection to the world around you, Pisces. Although this can take place by rearranging and bringing more life into your body and environment, an initial spirit of fresh possibility and willingness to release what is stale and outgrown is a necessity. In doing so, you can land upon a greater sense of capability and being resourced for life’s adaptations and evolutions. This will certainly be a month of growth in your material world and relationship with your body, but the serious litmus test is how settled you feel internally—the quality and clarity of your thoughts and inner world. Ideally, though this summer you’ll develop a stronger trust in yourself and an easier interface between your inner riches and outer quality of experience.
Aries: March 21-April 19Aries: March 21-April 19
The Mars/Jupiter conjunction is especially important for you, Aries, as it happens in your home sign. This signifies a spark of expansion that will play out over the coming year. Here, Jupiter is calling you into new ventures and adventures, to level up and act on the big dreams and desires brewing inside of you. Thus, this month is a great time to initiate some bigger change, to take some jump, leap or healthy risk. Although you don’t want to let this moment slip away, please don’t get impulsive or headstrong—make sure you’ve got at least a bit of a plan. Ideally, whatever you’re aiming at will require a good bit of care, and you can expect that much of this opportune, fertile energy will continue and develop throughout the next year.
Taurus: April 20-May 20Taurus: April 20-May 20
The start of the coming month will challenge you to keep up the pace, Taurus, so that it can consolidate into a healthy rhythm. Finding the right stride, you can find yourself breathing more easily, and maybe let yourself loosen your grip or take your hands off the handlebars, trusting your sense of balance and the strength in your legs. This can set the stage for an opportune spell at the end of Gemini Season, as your ruler Venus makes a conjunction with Uranus—you might keep an eye out for spontaneous side adventures, ways to create space for synchronicity, or simple moments where life is calling you into new ways of being. Ideally, these will feel like clear upgrades, but if you need to think of them as experiments or trial runs, that’s totally okay, too.
Austin police have charged Kaitlin Marie Armstrong, a local cyclist, for the murder of Moriah "Mo" Wilson.
Wilson, a rising star in the gravel and mountain bike community, was found dead with gunshot wounds inside an East Austin home on the night of May 11 when she was in town for the weekend Gravel Locos race in Hico, Texas.
Police believe Wilson was having a relationship with a man Armstrong was also in a relationship with. The man, another gravel cyclist, Colin Strickland, has since issued a statement on the murder.
In his statement, he said he had a brief romantic relationship with Wilson in October 2021 before he resumed his relationship with Armstrong, but that he remained friends with Wilson. "There is no way to adequately express the regret and torture I feel about my proximity to this horrible crime. I am sorry, and I simply cannot make sense of this unfathomable tragedy.
NEW: Austin professional cyclist Colin Strickland has just released a statement about the murder of cyclist Moriah Wilson, clarifying his relationship with her and expressing “torture about my proximity to this horrible crime.” pic.twitter.com/KnIna3mWrE
— Tony Plohetski (@tplohetski) May 20, 2022
Wilson, a 25-year-old Vermont native living in Colorado, had won a slew of races becoming a fan favorite. She had just become a full-time racer this year.
Anyone with information on this crime can contact Austin police at 512-974-TIPS or contact Crime Stoppers anonymously at 512-472-8477.
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