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Dr. MaryAnn Tran, an infectious disease specialist and regional section chief for Baylor Scott & White, just enrolled some of her COVID-19 patients in a treatment study.
<p>With her approval, they will receive convalescent plasma therapy—or plasma infusions from donors who have recovered from COVID-19—as part of a national study overseen by the Mayo Clinic and the U.S. Food and Drug Administration. </p><p>"Hopefully we'll get some more promising data and so we'll get better at knowing who the patients are who could benefit the most from it," Dr. Tran said.</p><p>Convalescent plasma therapy uses donations from recovered patients—or those who have convalesced—in the hopes that <a href="https://austonia.com/Coronavirus/testing-austin" target="_self"><u>their antibodies</u></a> aid those in need of treatment. Since We Are Blood began collecting <a href="https://weareblood.org/convalescent-plasma/" target="_blank">convalescent plasma donations</a> in mid-March, 91 COVID-19 patients have received treatment.</p><p>The wait time for infusions has dropped to less than 24 hours as the local nonprofit has shifted to operating at a surplus. Initially, the organization only accepted plasma from eligible donors who had tested positive for COVID-19, but now it is allowing people who have received <a href="https://austonia.com/Coronavirus/testing-austin" target="_self"><u>positive antibody test results</u></a> to donate, too. One donation can be used to treat multiple patients.</p><p>"For me, I didn't start enrolling patients until I heard from We Are Blood that there was ample supply," Dr. Tran said.</p><p>The expanded use of convalescent plasma therapy has improved morale for physicians and patients alike.</p><p>"It gives us a potential weapon to offer to patients where we otherwise don't have a lot of good options, outside of excellent support and care they're going to get in the hospital," Dr. Jeff Yorio, a hematologist-oncologist at Ascension Seton and Texas Oncology's Austin Central location. "It kind of gives us a chance to feel like we're actively doing something." </p><p>Convalescent plasma therapy has been used for more than a century to treat diseases such as the Spanish flu, diphtheria and Ebola, with varying levels of success. Despite this precedent, questions remain. </p><p>"There have been some patients where I have felt that their response was more rapid than I might otherwise expect, and I wonder if that's due to the convalescent plasma," said Dr. Matthew Robinson, an infectious disease physician at St. David's South Austin Medical Center. "But we have no way of knowing for sure."</p><p>While scientists know that patients exposed to the coronavirus develop antibodies, it is still unclear <a href="https://austonia.com/Coronavirus/covid-immunity" target="_self"><u>what level of immunity</u></a> those antibodies confer—or how long they may last. </p><p>As the national study continues, Dr. Robinson said he is excited to learn more about potential uses of convalescent plasma therapy, such as to treat patients with symptoms of COVID-19 who do not require hospitalization in an effort to prevent the disease from progressing, or as a prophylactic for health care workers to help them avoid contracting the disease altogether. </p><p>Convalescent plasma therapy also provides a chance for those who have recovered from COVID-19 to help others. </p><p>Dr. Tran, Dr. Yorio and Dr. Robinson each said their patients are not only interested in receiving the treatment—but also in becoming donors themselves when it is safe for them to do so.</p><p>"People can contribute and feel like, 'I'm doing my part,'" Dr. Robinson said. "It's just another aspect of this—patients helping patients." </p>
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A&M and Harvard testing century-old developing-world BCG tuberculosis vaccine for COVID fight
28 April
An effective vaccination for COVID-19, officials have been saying since the crisis began this winter, could be a year or more away.
In the meantime, scientists and the broader medical community are feverishly looking for ways to mitigate a virus that, at times with seeming randomness, spares many who catch it while bringing others to death's door. Or through it.
<p>Texas A&M University researchers, in concert with Harvard University and top hospitals in Texas and Los Angeles, this week are commencing a human trial with a drug that some international data indicates could be a promising interim treatment for COVID-19: the BCG vaccine, or bacille Calmette-Guerin. BCG wouldn't prevent COVID-19 entirely, but researchers are looking to prove that it could dampen the effects of the disease, creating a "trained immunity" that would save lives and curb the ravages of the disease in other cases.</p><p>The study is primarily funded with a $2.5 million grant from the Texas A&M system.</p><p>"If we get the data out in the next few months showing even a 10% effect on COVID-19, we could save hundreds, if not thousands, of lives," said Dr. Jeffrey Cirillo, a researcher in infectious and respiratory diseases with the Texas A&M Health Science Center in College Station. He said solid results would be available within a half year. "It allows us to buy time until we have a specific COVID-19 vaccine available."</p>
<img lazy-loadable="true" src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMzE3MDcwMC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYxMjA0NzY2N30.DIDkTsM1xoK-HRrMauuujqOT13L9Uugo_J7mQGjnrs4/img.jpg?width=980" id="4a8f2" class="rm-shortcode" data-rm-shortcode-id="003bcdf6f629b3740693570a335e3dc3" data-rm-shortcode-name="rebelmouse-image" />
Dr. Jeffrey Cirillo, Texas A&M University Health Science Center
<blockquote><em>Dr. Jeffrey Cirillo of Texas A&M University Health Science Center said results of the study could be available with six months.</em></blockquote>
<p>"If there was ever a time to invest in medical research, it is now," A&M Chancellor John Sharp said in a statement released by the A&M system. "I want to make sure [Cirillo] has what he needs to protect the world from more of the horrible effects of this pandemic."<br/></p><p>But Cirillo had two cautions against the sort of overexuberance that has led some people to prematurely pursue remedies mentioned by politicians or the media.</p><p>The clinical trial, first of all, is in its infancy. Recruitment of a hoped-for 1,800 frontline medical workers to volunteer in the randomized, double-blind study is just beginning, with only 30 on board as of Tuesday. That includes about a dozen participants in Round Rock, Cirillo said. Actual BCG vaccinations (or, in half the cases, a placebo) won't begin until clinicians have at least 100 volunteers.</p><p>(A&M asks medical workers in College Station, Temple, greater Austin, Dallas and Houston to contact Cirillo at: <a target="_blank"><u>jdcirillo@tamu.edu</u></a>.)</p><p>Beyond that, while the vaccine is FDA-approved for bladder cancer treatment and thus safe, just how much it buttresses immune systems against the effects of COVID-19 remains unclear.</p><p>"What we have seen in other contexts is that BCG has a positive effect on the immune response to viral and bacterial infections," Cirillo said. "But we're really trying to get people to be cautious and not try to get the vaccine at this point."</p><p>BCG has been in use since 1921 as a vaccination for childhood tuberculosis in at least 20 developing countries—hundreds of thousands of young children get it each year, he said—and more recently in the U.S. and other countries to fight cancer. It has not been used typically as a vaccination in the United States because of the extremely low rates of childhood TB here.</p><p>But according to a COVID-19 statistical review released in the past few weeks by an M.D. Anderson professor and three co-authors—a study still under peer review—countries that do not use it as a TB vaccination in children have almost 10 times the incidence of COVID-19 infection. And the combined <a href="https://fortune.com/2020/04/02/coronavirus-vaccine-tb-deaths/" target="_blank">fatality rate from COVID-19</a>—40 deaths per million residents—in about 155 countries without BCG vaccinations likewise is almost 10 times greater than in the 21 countries with widespread vaccination.</p><p>The World Health Organization, in <a href="https://www.who.int/news-room/commentaries/detail/bacille-calmette-gu%C3%A9rin-(bcg)-vaccination-and-covid-19" target="_blank">a notice </a>on its website about that comparison, warns against making too much of those numbers. Such studies, WHO says, could be subject to "significant bias" caused by unexplored differences between countries in "demographics and disease burden, testing rates for COVID-19 virus infections, and the stage of the pandemic in each country."</p><p>Cirillo said that his hopes for BCG are not based primarily on those numbers, in any case, because the effects of vaccinating infants would be unlikely to persist into adulthood. Instead, he said, other epidemiological studies of adult usage of the drug have shown mitigation of viral and other respiratory diseases.</p><p>And that beneficial effect occurs quickly, he said.</p><p>"In most cases, it appears to occur almost immediately, within a few days [of vaccination] to a certain degree," Cirillo said. "Certainly within two to three months, you see a fairly robust response."</p><p>Already, a clinical trial of a similar strain of BCG (one not approved by the FDA) with 4,000 people<a href="https://www.sciencemag.org/news/2020/03/can-century-old-tb-vaccine-steel-immune-system-against-new-coronavirus" target="_blank"> in Australia is underway</a>, and Cirillo said it, too, holds promise. But Cirillo said manufacturing capacity already exists in the U.S. for the BCG variety in the A&M study with pharmaceutical giant Merck, as well as in factories in Canada, India and Italy.</p><p>"I think we can do it," if the drug proves beneficial in the coming months, Cirillo said. "It has been produced at a national scale in the past. So ramping up would not take as long as other vaccines." </p>From Your Site Articles
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